Introducing HYLO Dual Intense


A powerful combination of high molecular weight Hyaluronic Acid and Ectoin® that delivers instant and long lasting relief.

Longer lasting benefits with High Molecular Weight Hyaluronic Acid





Dry Eye Disease (DED) is a growing public health concern that affects millions of people worldwide 8

A study of ~90,000 individuals underline the important of recognising dry eye as a serious disorder. The results showed that DED is associated with reductions in all domains of vision-related quality of life including:8, 9


Self-perceived driving ability is greatly affected, especially in highly symptomatic patients. This highlights the importance of discussing driving limitations with dry eye patients.

Mental Health

Studies indicate that not having a diagnosis is associated with worse mental health-related quality of life in those with severe DED.

Vision-related Quality of Life

Impact vision-related QOL was similar or greater in DED vs:
- Macular degeneration
- Glaucoma
- Retinal detachment
- Allergic conjunctivitis

High Molecular Weight Hyaluronic Acid

The superior performing HA for the ocular surface


Natural protection and stability

Two hard working ingredients for one more stable tear film

Ectoin® organises the water in the mucoaqueous layer giving the tear film structure and stability13
High molecular weight HA locks in more water10 and binds with the mucins to stabilise the mucoaqueous layer3
Ectoin® stabilises the lipid layer of the tear film preventing evaporation13
Ectoin® binds water over exposed epithelial cells11 and acts as an osmoprotectant at the base of the corneal surface15
HYLO DUAL INTENSE® is ideal for patients with moderate to severe dry eye disease that need a step up in management:
Patients with insufficient symptomatic relief from their current lubricant
Present with more intense inflammatory symptoms such as burning and stinging
Need more protection from their drop whilst not compromising on lubrication
Need a more viscous formula for a more comforting effect
Present with corneal staining indicating epithelial damage
Present with more intermittent fluctuations of vision due to dry eye
Patients required to instil their current lubricant 4-6 times/daily

Cost Savings vs The Competition

Take a look at how HYLO DUAL INTENSE® can offer substantial cost savings compared to preservative-free multi-dose alternatives.


  1. Hynnekleiv, L., et al,. (2022). Hyaluronic Acid in the treatment of dry eye disease. Acta Ophthalmologica, 100(8), 844-860.
  2. Arshinoff et al., (2021). Role of rheology in tears and artificial tears. Journal of Cataract and Refractive Surgery, 47(5), 655-661.
  3. Guarise, C., et al. 2023. The role of high molecular weight Hyaluronic Acid in mucoadhesion on an ocular surface model. Journal of Mechanics and Behaviour of Biomedical Materials, 143, 105908.
  4. Aragona, P., et al. 2019 Physicochemical Properties of Hyaluronic Acid- Based Lubricant Eye Drops. Translational Vision Science & Technology, 8(6).
  5. Marinho, A., Nunes, C., & Reis, S. (2021). Hyaluronic Acid: A Key Ingredient in the Therapy of Inflammation. Biomolecules, 11(10), 1518.
  6. Van Setten, G.B., et al 2020. high molecular weight Hyaluronan Promotes Corneal Nerve Growth in Severe Dry Eyes. Journal of Clinical Medicine, 9(12), 3799.
  7. Kojima, T., et al. (2020) The Effects of high molecular weight Hyaluronic Acid Eye Drop Application in Environmental Dry Eye Stress Model Mice. International Journal of Molecular Sciences, 21(10), 3516.
  8. Morthen et al., 2022. The vision-related burden of dry eye. The Ocular Surface, 23, 207-215.
  9. Morthen et al., 2021. The physical and mental burden of dry eye disease: a large population-based study investigating the relationship with health-related quality of life and its determinants. The Ocular Surface, 21, 107-117.
  10. Kuhlmann, A.U., et al, 2011. Ectoine and hydroxyectoine as protectants against osmotic and cold stress: uptake through the SigB-controlled betaine-choline-carnitine transporter-type carrier, Journal of bacteriology, 193(18).
  11. Dwivedi, M., et al 2014. Biophysical investigations of the structure and function of the tear fluid lipid layers and the effect of ectoine. Part B: artificial lipid films.Biochimica et Biophysica Acta (BBA)-Biomembranes, 1838(10), pp.2716-2727.
  12. Galinski, E. A. (1993). “Compatible solutes of halophilic eubacteria: molecular principles, water-solute interaction, stress protection.” Experientia 49: 487.
  13. Werkhäuser, N., et al ., 2014. Treatment of allergic rhinitis with ectoine containing nasal spray and eye drops in comparison with azelastine containing nasal spray and eye drops or with cromoglycic acid containing nasal spray. Journal of allergy, 2014.
  14. Müller-Lierheim, W. G. K. (2020). Why Chain Length of Hyaluronan in Eye Drops Matters. Diagnostics, 10(8), 511.
  15. Bownik, A., et al. 2016. Ectoine as a promising protective agent in humans and animals. Arhiv za higijenu rada i toksikologiju, 67(4), pp.260-264.

HYLO Dual Intense vs Thealoz Duo




Pack price containing 300 drops (Tariff price)




Drop administration per day

3 drops*

4 drops*

6 drops*

Treatment duration based on daily drop count

50 days

37.5 days

25 days

Annual cost per patient




Cost per ‘000 patients




Savings per ‘000 patients when switched to HYLO DUAL INTENSE




*Per Eye